In English
NIDA

NIDA Notes Advanced Search

Specific Drugs

Drug Topics

Temas relacionadas

Do you like these search results?

See all RSS Feeds

Your search for Addiction Science returned 100 results. Search again.

Basic Science

A Genetic Nexus of Obesity and Smoking

Research shows that some gene variants that influence body mass index also shape smoking behaviors.

Bulletin Board

Student-Scientists Present Award-Winning Research at NIDA

Four high school students were honored for their work regarding e-cigarettes, the GABAA neuroreceptor, and adolescent multitasking.

Basic Science

Dr. Antonello Bonci Q & A: Lighting Up the Brain To Shut Down Cocaine Seeking

The Scientific Director of NIDA’s Intramural Research Program talks about switching off animals’ compulsive cocaine seeking by optogenetically activating the prefrontal cortex, and the implications of this work for people. In an accompanying podcast, Dr. Bonci walks viewers through experiments that showed that prefrontal cortex activity levels may constitute a simple switch controlling whether or not animals compulsively seek cocaine.

Basic Science

Gene Variants Reduce Opioid Risks

Two recent studies suggest that genotyping may enable clinicians to base therapies on individual patients’ potential responsiveness to opioid drugs’ therapeutic effects and vulnerability to their harmful effects.

Basic Science

New Insight Into How Cues Cause Relapse to Cocaine

A brain response occurs in the nucleus accumbens when rats encounter a cue that they associate with previous cocaine self-administration, but not a cue associated with a pleasurable non-drug experience. Moreover, the response correlates in time and intensity with the animals’ cue-induced relapse to cocaine-seeking.

NIDA @ Work

Dr. Joni Rutter Q&A: How Basic Science Is Tackling Addiction

One of NIDA’s goals is to try to understand the individual differences that contribute to whether or not someone who takes a drug will become addicted to it. Dr. Rutter’s research focuses on three types of differences: Environmental, developmental, and genetic and epigenetic.

Basic Science

Methamphetamine Alters Brain Structures, Impairs Mental Flexibility

Methamphetamine alters brain structures involved in decision-making and impairs the ability to suppress habitual behaviors that have become useless or counterproductive. The two effects were correlated, indicating that the structural change underlies the decline in mental flexibility.

Basic Science

Stress-Induced Enzyme Compounds Methamphetamine Neurotoxicity

Ketoprofen, an anti-inflammatory agent commonly prescribed to treat arthritis, reduces neuronal damage in rats that have been exposed to chronic stress and methamphetamine. If this finding of a recent NIDA-supported study extrapolates to humans, anti-inflammatory medications may gain a place in the treatment of methamphetamine addiction.

Basic Science

Prefrontal Cortex Stimulation Stops Compulsive Drug Seeking in Rats

Researchers have shut down laboratory rats’ compulsive cocaine seeking by stimulating an area of the animals’ prefrontal cortex. The finding raises the possibility that stimulating neurons in this brain area may weaken or break cocaine’s grip on the behavior of people who are addicted to the drug.

Bulletin Board

Dr. Evan D. Kharasch Joins the Institute of Medicine

Dr. Kharasch is a NIDA-funded researcher known for a broad range of research into how drugs are metabolized in the body.

Basic Science

Study Finds Genetic Influence on African Americans’ Smoking

A meta-analysis of 13 genome-wide association studies of African Americans’ smoking patterns confirms the significance of genetic variation in region 15q25.1. The analysis also tentatively implicates several genome locations that have not previously been associated with smoking behaviors.

NIDA @ Work

Dr. Marilyn Huestis Q & A: Matching Drug Effects to Drug Concentrations

Dr. Marilyn Huestis of NIDA’s Intramural Research Program talks about conducting research on drug effects with human subjects, developing tests to help law enforcement identify drugged drivers, and an assay to help identify children whose prenatal exposure to anti-HIV drugs may put them at risk for adverse developmental outcomes.

Basic Science

Stimulants in “Bath Salts” Produce Effects Similar to MDMA

Mephedrone and methylone, two stimulants commonly found in designer drugs such as “bath salts,” act on the brain much like MDMA (Ecstasy).

Basic Science

Study Pinpoints Cognitive Deficits Due to Cocaine, Finds Potential for Recovery

New research demonstrated that, in rhesus monkeys, ongoing cocaine exposure weakens two brain functions that people require for successful behavioral change: cognitive flexibility and memory. But the study determined that these changes may not be permanent.

Treatment

N-Acetylcysteine Postsynaptic Effect Limits Efficacy

Clinical trials of N-acetylcysteine to help people recovering from drug abuse avoid relapse have demonstrated only moderate efficacy. New NIDA-supported research shows that while a low dose of the medication activates receptors associated with lowered drug-seeking behavior, a higher dose appears to activate receptors associated with increased drug-seeking behavior. The result suggests that a medication or combination of medications that stimulate the receptor GluR2/3 and block mGluR5 may work better than N-acetylcysteine alone.

Treatment

Animation: Building an Anti-Drug Vaccine

The immune system has an extraordinary ability to recognize compounds foreign to the body and eliminate them. NIDA-sponsored scientists are working to harness this ability to create vaccines that will protect individuals against the psychogenic and addictive effects of abused drugs. This animation shows one of the most promising strategies, which has already yielded partial success in producing effective vaccines against nicotine, cocaine, and other drugs.

Bulletin Board

Dr. David Jentsch Receives the 2011 Waletzky Memorial Award

Dr. J. David Jentsch is the recipient of the 2011 Jacob P. Waletzky Memorial Award for Innovative Research in Drug Addiction and Alcoholism. Dr. Jentsch and colleagues at the University of California, Los Angeles, are studying genetic and neurochemical factors that influence individual differences in inhibitory control.
Basic Science

Investigators Map Functional Networks in the Rat Brain

Researchers have mapped the fundamental functional organization of the rat brain and shown that it resembles that of the human brain.
NIDA @ Work

Women and Sex/Gender Differences Research Program

NIDA’s Women and Sex/Gender Differences Research Program focuses on gender-specific addiction risk factors and treatment needs.
Basic Science

Well-Known Mechanism Underlies Benzodiazepines' Addictive Properties

New research establishes that benzodiazepines cause addiction in a way similar to that of opioids, cannabinoids, and the club drug GHB. The discovery opens the door to designing new benzodiazepines that counteract anxiety but are not addictive.
Basic Science

New Method Uncovers How Internal States Influence the Living Brain to Change Behavior

In an innovative NIDA-funded study, published in Cell, scientists introduced a modified dopamine receptor gene into the brain of a living vinegar fly
Basic Science

In Animals, Receptor Puts Brakes on Nicotine Consumption

New research suggests that differences in tobacco consumption reflect, in part, differences in the functional efficacy of a specific type of receptor in a pathway of the brain. In animal studies, nicotinic acetylcholine receptors with the α5 subunit played a key role in producing aversive responses to nicotine, thereby dissuading further consumption of the drug.

Treatment

Stimulant Abusers' Regard for Future Improves With Memory Training

Researchers correlate stimulant abusers’ improved performance on a memory training exerc ise with reductions in delay discounting.

Director's Perspective

NIDA's Drug Abuse Research Advances Science as a Whole

NIDA Director Dr. Nora D. Volkow summarizes instances where discoveries with broad implications for human health arose from scientists seeking answers to addiction problems.

Basic Science

Molecular Alterations of DNA Contribute to Persistence of Memory

In a new series of studies tracing the molecular events that occur in the brain as memories are formed and preserved, researchers find that certain epigenetic changes may promote vulnerability to relapse.
NIDA @ Work

Office Meets Dynamic Challenges of Diversity

Describes NIDA’s Special Populations Office which promotes addiction science that examines health disparities and foster research careers among members of underrepresented communities.
Basic Science

Cocaine Alters Production of Hundreds of Proteins

Describes research findings that show that chronic cocaine abuse may change the production of many proteins in the neurons of the brain’s reward system, aiding in our understanding how the drug causes addiction.

Bulletin Board

Three Scientists Join Advisory Council

Announces three new NIDA National Advisory Council on Drug Abuse members and describes their drug abuse and addiction research experience.
Bulletin Board

Addiction Science Award Winners Announced

Announces the 2010 high school student recipients of the Addiction Science Awards and describes their winning addiction-focused projects.
Bulletin Board

Program Enhances Physician Knowledge on Substance Abuse

Reports on an evaluation of the Chief Resident Immersion Training (CRIT) program to assess its effectiveness in improving knowledge, confidence, and preparedness to diagnose, manage, and teach about substance abuse.
Bulletin Board

NIDA Grantee Wins Prize for Genetics Web Sites

Announces the recipient of an award for online resources in education, Dr. Louisa Stark, who developed two interactive Web sites on genetics.
NIDA @ Work

Workgroup Keeps NIDA on the Cutting Edge of Brain Science

Reports on the objectives and activities of the Neuroscience Consortium and their impact on Institute drug abuse research programs and initiatives.

Basic Science

Lower Levels of Dopamine-Regulating Receptors Among Novelty Seekers

Describes research results reporting that people who favor novelty have lower-than-average availability of a receptor that inhibits dopamine's release from neurons, which likely stimulates the activity of reward circuits.

Basic Science

Brain Adaptation May Dampen Effects of Cocaine

Reports evidence that a cocaine-induced change in the structure of brain cells represents an adaptive response that may limit the drug’s impact.
Bulletin Board

Dr. Geoffrey Schoenbaum Receives the Waletzky Memorial Award

Announces the recipient of a 2009 award for innovation in research on drug addiction and alcoholism and with a focus on the changes that occur in the brain after exposure to drugs.
Basic Science

Crack Cocaine Promotes Progression of HIV Infection to AIDS

Reports on two studies showing a high prevalence of HIV infection and more rapid progression to disability and death among drug abusers.
Bulletin Board

NIDA Curriculum Piques Students' Interest in Addiction Careers

Describes an eight-module web-based curricula that introduces addition research to graduate students of nursing, dentistry, and medicine.
Basic Science

Brain Opioid Receptor Levels Predict Time to Cocaine Relapse

Describes study findings revealing that cocaine abusers who maintain high levels of a certain receptor in their brain during early abstinence relapse sooner than abusers whose levels drop.
Bulletin Board

French Government Honors Dr. Volkow

Announces the 2009 International Prize, awarded by the French Institute of Health and Medical Research, to NIDA Director Dr. Nora D. Volkow.
Bulletin Board

Reality Videos Bring NIDA Scientists to Web Site for Teens

Highlights new video clips on NIDA's Web site for teens that explore the dangers of drug abuse and that address questions from youth and their parents on the topic.
NIDA @ Work

Workgroup Directs Search for Genes That Influence Addiction

Highlights NIDA’s research portfolio to identify the genes and genetic processes responsible for a person’s vulnerability to drug abuse.

Basic Science

Peer Interaction Enhances Adolescent Rats' Drug Reward

Describes an animal study reporting that peer interaction enhances adolescent rats’ drug reward and discusses the impact of these findings to future research on drug reward in social context.
Basic Science

Genetic Overlap Between Substance Abuse and Bipolar Disorder

Describes a literature analysis reporting on the prevalence of people with bipolar disorder who also have a substance use disorder and discusses the genetic link that may contribute to this comorbidity.

Bulletin Board

How-To Guides Provide Tips for Publishing Addiction-Related Articles

Describes a book and online tutorial for young investigators of addiction science that provides tips for publishing their studies in scholarly journals.
Director's Perspective

NIDA's 35th Anniversary: Science Focused on Solutions

Commemorates NIDA’s 35th anniversary and highlights some of the major accomplishments since the Institute’s inception in 1974.

Basic Science

Studies Link Family of Genes to Nicotine Addiction

Reports study results suggesting that genes for several acetylcholine receptor proteins influence early smoking responses and the likelihood of nicotine dependence.

Basic Science

Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

Basic Science

Extended Cocaine Exposure Impairs Cognitive Function in Rats

Reports an animal study presenting evidence that cocaine causes cognitive deficits that can persist well into abstinence.

Bulletin Board

Annual Event Teaches Students Brain Science

Highlights activities held during Brain Awareness Week for students in Maryland, Virginia, and Washington, DC, to learn about brain anatomy and function.

NIDA @ Work

DESPR Identifies Drug Abuse Trends and Seeks Solutions

Discusses the work of NIDA’s Division of Epidemiology, Services and Prevention Research, organized to track drug use and provide empirically based information for researchers and service providers.
Bulletin Board

NIDA Awards Prizes at International Science Fair

Announces the 2009 high school student recipients of the Addiction Science Awards and describes their winning addiction-focused projects.

Basic Science

Nicotine Boosts Mood, Brain Dopamine Levels

Highlights findings from a study showing that nicotine triggers a surge in levels of the neurotransmitter dopamine in the brain's main reward area for cigarette smokers.

Director's Perspective

Substance Abuse Among Troops, Veterans, and Their Families

Highlights the need for research to assess and find solutions to a potential rise in substance abuse among service men and women, veterans, and their families.

Basic Science

Methamphetamine Turns Helper Cells Into Destroyers

Describes research providing evidence that chronic methamphetamine abuse is associated with increased microglial cell activity in the brain leading to neurodegeneration.

Bulletin Board

R. Christopher Pierce Receives the Waletzky Memorial Award

Announces the recipient of a 2009 award for innovation in research on drug addiction and alcoholism whose research focuses on the cellular changes that occur in response to chronic cocaine abuse.

Basic Science

Receptor Complexes Link Dopamine to Long-Term Neuronal Effects

Reports on a discovery of previously unrecognized dopamine receptors in the brain that when triggered by drug abuse lead to potentially long-term neuronal effects.

Basic Science

Drug Cues Outside Awareness Rapidly Trigger Brain's Emotion Centers

Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.

Basic Science

Sensory Aspects of Smoking May Counter Bad Mood, Craving

Describes study findings revealing that the act of smoking, apart from actual or expected nicotine delivery, may soothe a smoker's negative mood.

Basic Science

Methamphetamine Abuse Alters Response to Facial Cues

Highlights research showing methamphetamine abusers may have more difficulty than nonabusers in responding with empathy and self-control to people who are experiencing intense emotions.

Basic Science

Damage to Brain Area May Immediately Halt Cigarette Addiction

Describes a study among people who had sustained brain injuries to investigate whether certain damaged areas of the brain are associated with the ability to quit smoking.

Basic Science

New Tracer for Nicotinic Receptors Promises Improved Specificity

Reports on NIDA researchers who developed a new tracer compound that binds readily to nicotine receptors and enhances positron emission tomography images.

Bulletin Board

Universities Offer Online Master's Program in Addiction Studies

Describes a consortium of three universities that launched a 12-month intensive online program last August that leads to a master's degree in addiction studies.

Director's Perspective

Stimulus Money Will Fund a Surge in Knowledge

Describes NIDA’s drug abuse and addiction research priorities for the use of the American Recovery and Reinvestment Act of 2009 funds.

Basic Science

Adolescent Rats Self-Administer More Nicotine Than Adults

Highlights an animal study involving the self-administration of nicotine among adolescent and adult rats to gain understanding of their potential vulnerability to the substance.

Bulletin Board

NIDA Initiates Pediatrics Symposium on Adolescent Health

Presents highlights of a symposium sponsored by NIDA in October 2008 to discuss adolescent brain and cognitive development and consider the impact of drug abuse on young people.

Basic Science

Low Dopamine Receptor Availability May Promote Cocaine Addiction

Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.

Basic Science

Cocaine Locks Rats Into Unrewarding Behaviors

Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.

Basic Science

Methamphetamine Abusers Show Increased Distractibility

Highlights findings from a study of former methamphetamine abusers showing evidence of impairment in areas of the brain known to influence cognition, emotion, and decision making.

Basic Science

Long-Term Cocaine Self-Administration Depresses Brain Activity

Discusses research exploring how widespread the reduction of neural activity is in the brain with chronic exposure to cocaine.

Basic Science

Brain Proteins Differ in Cocaine-Overdose Victims

Describes research findings showing differences in protein concentrations in the brain pleasure centers of people who died from cocaine overdose as compared with those who did not abuse the drug.

Bulletin Board

Henry Yamamura Obituary

Remembers Henry I. "Hank" Yamamura, an eminent neuropharmacologist who pioneered radioligand binding assays, contributing valuable knowledge about neurotransmitter transporters and receptors.

Basic Science

Imaging Studies Elucidate Neurobiology of Cigarette Craving

Reports on three separate imaging studies illuminating the neurobiology of cigarette craving.

Basic Science

Immune System Plays Unexpected Role in Brain Development

Describes research findings demonstrating that the immune system participates in the shaping of brain circuits during a child's development, a finding that may shed light on the origins of neurodegenerative diseases.

Basic Science

Optical Technologies Expand Vistas Into the Brain

Describes new tools under development, including one to visualize cells deep in the brain and another one that remotely activates brain cells.

Basic Science

New Technique Links 89 Genes to Drug Dependence

Presents research findings linking 89 genes to drug abuse and dependence, found using genome-wide association studies, a new technique for identifying genes.

Bulletin Board

NIDA Bestows Prizes at International Science Fair

Announces the three winners of the NIDA and Scholastic Corporation 2008 Addiction Science Awards honoring high school students’ award-winning addiction-related projects.

Basic Science

Animal Studies Elaborate Toluene's Effects

Reports on evidence that toluene abuse can harm the nervous system and body, although scientists know relatively little about its specific actions.

Director's Perspective

Neuroscience Blueprint Promotes Efficiency, Synergy

Describes a knowledge- and resource-sharing system for NIH-funded neuroscientists to access to data, advanced research tools, and technical assistance.

Basic Science

Mice With Genetic Alteration Eschew Cocaine

Reports on a study involving researchers who successfully desensitized mice to cocaine by genetically altering their dopamine transporters.

Bulletin Board

Booklet Explains the Science of Addiction

Describes a booklet that explains what scientists know about how drug addiction changes the brain and affects behavior and clears up misconceptions about drug addiction.

Basic Science

Not All Mesolimbic Dopamine Neurons Are Alike

Reports on research showing that the neurons that deliver dopamine to two regions of the brain's mesolimbic reward system respond differently to opioids, an important finding for drug treatment research.

Epidemiology

Alcohol Abuse Makes Prescription Drug Abuse More Likely

Reports on results from a study showing that men and women with alcohol use disorders are more likely to report nonmedical use of prescription drugs than people who don't drink at all.

Long-Term Cocaine Abuse Linked With Impaired Heart Function

Summarizes research on the effects of long-term regular cocaine abuse on the cardiovascular system in African Americans.
Basic Science

Chromosome 17 Harbors Opioid Dependence Genes

Describes the work of researchers who have found a statistical link between one region on chromosome 17 and an increased risk of opioid dependence.

Basic Science

Cocaine Can Mobilize Stored Dopamine

Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.

Director's Perspective

Epigenetics: The Promise of a New Science

Discusses the role of epigenetics, the study of cellular mechanisms that control gene expression and its impacts on health and behavior, in addiction research.

Researchers Develop a New Tracer for Cannabinoid Receptor

Describes a new chemical tracer that binds specifically to cannabinoid receptors making it potentially useful in future research to clarify the relationship between the receptors and drug abuse.
Director's Perspective

NIDA Will Contribute to Obesity Research

Describes an NIH-wide obesity task force and research plan and explores some of the links between addiction and compulsive eating.

NIDA @ Work

NIDA's Newest Division Mines Clinical Applications From Basic Research

Describes the role of the Division of Clinical Neuroscience and Behavioral Research in NIDA’s drug abuse and addiction research plan.

Basic Science

Gene Experiment Confirms a Suspected Cocaine Action

Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.

Tracing NET

Describes research that has led to the development of a new tool, a new radiotracer, for studying the neurobiology of depression, attention deficit hyperactivity disorder, and stimulant abuse.
Basic Science

Impacts of Drugs on Neurotransmission

Discusses the central importance of studying drugs' effects on neurotransmission and describes some of the most common experimental methods used in this research.

Basic Science

Exposure to Morphine During Early Adolescence Sensitizes Rats as Adults

Presents highlights of a study indicating that exposure to morphine during adolescence may increase sensitivity to the drug during adulthood.

Neuropeptide Promotes Drug-Seeking and Craving in Rats

Reports on two studies indicating that orexin, a neuropeptide that stimulates eating and regulates wakefulness, also fosters animals' drug seeking and craving responses to drugs.
Bulletin Board

NIDA Investigator Receives 2006 Waletzky Memorial Award

Announces the recipient of a 2006 award for innovation in research on drug addiction and alcoholism, Dr. Yavin Shaham, and describes his research which focused on the stress-induced drug use relapse.

Scientists Pinpoint Brain's Sweet Tooth

Reports on research that successfully traced rats’ liking for sweets to a 1-cubic millimeter site in the medial shell of the nucleus accumbens in the brain.

Brain Changes Accompany Cocaine Withdrawal

Summarizes an animal study of the neural changes in the amygdala portion of the brain that occur as a result of cocaine exposure followed by withdrawal of the drug.

Cocaine Craving Activates Brain Reward Structures; Cocaine "High" Dampens Them

Reports on a study that documenting changing emotional and neurobiological responses to cocaine with successive doses during a single session of drug taking.

Nicotine Alters the Developing Rat Brain

Describes animal studies that suggested exposure to the drug during gestation or adolescence may cause lasting alterations in reward and motivation circuits.
Bulletin Board

NIDA's National Advisory Council Welcomes New Members

Introduces four new members to NIDA’s National Advisory Council on Drug Abuse, including Drs. Warren K. Bickel, Ellie E. Schoenbaum, and Marina E. Wolf, and Ms. Janet Wood.
NIDA Notes

Tags

Drug Topics

Drugs of Abuse

Population Groups

Related Topics

Toma el reto nacional sobre el coeficiente intelectual (CI) sobre las drogas