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Your search for Genetics returned 28 results. Search again.

Basic Science

A Genetic Nexus of Obesity and Smoking

Research shows that some gene variants that influence body mass index also shape smoking behaviors.

Basic Science

Gene Variants Reduce Opioid Risks

Two recent studies suggest that genotyping may enable clinicians to base therapies on individual patients’ potential responsiveness to opioid drugs’ therapeutic effects and vulnerability to their harmful effects.

NIDA @ Work

Dr. Joni Rutter Q&A: How Basic Science Is Tackling Addiction

One of NIDA’s goals is to try to understand the individual differences that contribute to whether or not someone who takes a drug will become addicted to it. Dr. Rutter’s research focuses on three types of differences: Environmental, developmental, and genetic and epigenetic.

Basic Science

Study Finds Genetic Influence on African Americans’ Smoking

A meta-analysis of 13 genome-wide association studies of African Americans’ smoking patterns confirms the significance of genetic variation in region 15q25.1. The analysis also tentatively implicates several genome locations that have not previously been associated with smoking behaviors.

Basic Science

Male Rats’ Cocaine Exposure Affects Their Offspring’s Drug Responses

In a surprising finding, male rats who used cocaine sired male offspring who later exhibited blunted responses to the drug. Researchers determined the cause was an epigenetic alteration.

Basic Science

Stress Receptor Mediates Lifelong Consequences of Early Trauma

NIDA-supported research suggests that glucocorticoid receptor levels during early brain development affect the hard wiring of neural circuits that shape an individual’s basic emotional makeup. In mice, overexpression of the glucocorticoid gene in the first weeks after birth increased anxiety and response to cocaine in adulthood. These findings may help researchers understand the genetic background and the developmental trajectory of addiction.

Bulletin Board

PhenX Toolkit Provides Standard Measures for Research

NIDA researchers working with human subjects now have a new resource at their fingertips: the PhenX Toolkit’s new Substance Abuse and Addiction (SAA) Collection. The Toolkit is designed to provide standardized measures, vetted and approved by the field, to help researchers compare and combine data from multiple studies.
Bulletin Board

Dr. David Jentsch Receives the 2011 Waletzky Memorial Award

Dr. J. David Jentsch is the recipient of the 2011 Jacob P. Waletzky Memorial Award for Innovative Research in Drug Addiction and Alcoholism. Dr. Jentsch and colleagues at the University of California, Los Angeles, are studying genetic and neurochemical factors that influence individual differences in inhibitory control.
Prevention

Individual Differences in Decisionmaking Style May Predict Teen Problems

Reports on the relative influence of genes versus environment on adolescents’ choices that involve delayed gratification.

Basic Science

Resting Brain Studies Shed New Light on Vulnerabilities

Individuals with weak signaling in a nicotine-sensitive brain circuit were more vulnerable to nicotine dependence than those with stronger signaling, according to a study conducted while the subjects’ brains were in a resting state. A second resting-state study finds that the same circuit appears to mediate dependence associated with a genetic risk factor for smoking.

Basic Science

Gene Influences Impact of Maternal Smoking on Children's Behavioral Problems

Describes research showing that the combination of prenatal smoking exposure and specific genes increases children’s and adolescent’s risk for behavior problems.
Prevention

Parental Supervision and Genetics Interact To Influence Nicotine Addiction

Reviews research indicating that both parental influence and certain genes interact to influence nicotine addiction and that parental monitoring may play a role in reducing risk.

Bulletin Board

NIDA Grantee Wins Prize for Genetics Web Sites

Announces the recipient of an award for online resources in education, Dr. Louisa Stark, who developed two interactive Web sites on genetics.
Bulletin Board

Three Scientists Join Advisory Council

Announces three new NIDA National Advisory Council on Drug Abuse members and describes their drug abuse and addiction research experience.
NIDA @ Work

Workgroup Directs Search for Genes That Influence Addiction

Highlights NIDA’s research portfolio to identify the genes and genetic processes responsible for a person’s vulnerability to drug abuse.

Basic Science

Genetic Overlap Between Substance Abuse and Bipolar Disorder

Describes a literature analysis reporting on the prevalence of people with bipolar disorder who also have a substance use disorder and discusses the genetic link that may contribute to this comorbidity.

Basic Science

Studies Link Family of Genes to Nicotine Addiction

Reports study results suggesting that genes for several acetylcholine receptor proteins influence early smoking responses and the likelihood of nicotine dependence.

Director's Perspective

NIDA's 35th Anniversary: Science Focused on Solutions

Commemorates NIDA’s 35th anniversary and highlights some of the major accomplishments since the Institute’s inception in 1974.

NIDA @ Work

DESPR Identifies Drug Abuse Trends and Seeks Solutions

Discusses the work of NIDA’s Division of Epidemiology, Services and Prevention Research, organized to track drug use and provide empirically based information for researchers and service providers.
Treatment

Smokers Who Quit May Have Genetic Advantage

Describes research providing evidence that genes may influence how successful a person is in quitting smoking and which cessation technique may work best for them.

Basic Science

Manic Mice Show Heightened Sensitivity to Rewards

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

Basic Science

Ethnic Groups Have Contrasting Genetic Risks for Nicotine Addiction

Describes research exploring differences and similarities in the genetic profiles of African-Americans and European-Americans who are heavy smokers.

Basic Science

New Technique Links 89 Genes to Drug Dependence

Presents research findings linking 89 genes to drug abuse and dependence, found using genome-wide association studies, a new technique for identifying genes.

Basic Science

Mice With Genetic Alteration Eschew Cocaine

Reports on a study involving researchers who successfully desensitized mice to cocaine by genetically altering their dopamine transporters.

Director's Perspective

Epigenetics: The Promise of a New Science

Discusses the role of epigenetics, the study of cellular mechanisms that control gene expression and its impacts on health and behavior, in addiction research.

Basic Science

Cocaine Can Mobilize Stored Dopamine

Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.

Basic Science

Chromosome 17 Harbors Opioid Dependence Genes

Describes the work of researchers who have found a statistical link between one region on chromosome 17 and an increased risk of opioid dependence.

Director's Perspective

Genes and Smoking

Reports on the research underway to identify gene variations associated with nicotine addiction and the interaction of genetic makeup, experiences, and surroundings to addiction.

NIDA Notes

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