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Investigators Map Functional Networks in the Rat Brain

Researchers have mapped the fundamental functional organization of the rat brain and shown that it resembles that of the human brain.

Odds of quitting smoking affected by genetics

Genetics can help determine whether a person is likely to quit smoking on his or her own or need medication to improve the chances of success, according to research published in today’s American Journal of Psychiatry.


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Home Visits by Nurses to Low-Income First-Time Mothers Yield Enduring Benefits

A program involving home visits by nurses to low-income first-time mothers, starting during pregnancy and extending into the second year of their children’s lives, has a positive and long-lasting impact on families. Children who participated in the program were less likely than others to report having used alcohol, cigarettes, or marijuana at age 12.

Cognitive Strategy Reduces Craving by Altering Brain Activity

While viewing images of cigarettes, smokers reported milder cravings when they shifted their focus from the pleasures of smoking to its harmful effects. Brain imaging showed a correlation between the reductions in craving and altered activity levels in regions associated with emotional regulation and reward.

Tobacco Smokers Have High Probability of Transition to Dependence

First-time smokers have a much higher chance of eventually becoming dependent than first-time users alcohol, cannabis, and cocaine.

Vouchers Improve Mothers’ Smoking Abstinence and Newborns’ Weight

Pregnant women who received financial incentives to refrain from smoking during late pregnancy were more successful at remaining abstinent and less likely to have babies with low birth weight, according to data from three trials.

In Animals, Receptor Puts Brakes on Nicotine Consumption

New research suggests that differences in tobacco consumption reflect, in part, differences in the functional efficacy of a specific type of receptor in a pathway of the brain. In animal studies, nicotinic acetylcholine receptors with the α5 subunit played a key role in producing aversive responses to nicotine, thereby dissuading further consumption of the drug.

Nicotine Dependence Linked to Higher Rates of Mental Disorders Among Teens

A study of teenagers in Chicago public schools finds higher rates of psychiatric disorders among those with more symptoms of nicotine dependence.

NIDA Announces Avant-Garde Medication Development Awards

Dr. Thomas Kosten of Baylor College of Medicine and Dr. Peter Burkhard of the University of Connecticut are the recipients of NIDA’s 2011 Avant-Garde Awards for Innovative Medication Development Research. Dr. Kosten is developing a vaccine against methamphetamine abuse and Dr. Burkhard is developing a vaccine to counter nicotine addiction.

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