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Combined Treatments Improve Dual Abstinence

Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.

Manic Mice Show Heightened Sensitivity to Rewards

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

Methadone Therapy in Prison Benefits Men a Year Out

Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.

Extended Cocaine Exposure Impairs Cognitive Function in Rats

Reports an animal study presenting evidence that cocaine causes cognitive deficits that can persist well into abstinence.

R. Christopher Pierce Receives the Waletzky Memorial Award

Announces the recipient of a 2009 award for innovation in research on drug addiction and alcoholism whose research focuses on the cellular changes that occur in response to chronic cocaine abuse.

Test Substance Attenuates Signs of Cocaine Withdrawal in Rats

Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.

Recovery May Be Harder for Adolescents, Animal Study Suggests

Reports animal study findings that suggest adolescents' heightened sensitivity to drug reward puts them at enhanced risk of addiction and may also increase their challenges in recovery.

Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

Brain Opioid Receptor Levels Predict Time to Cocaine Relapse

Describes study findings revealing that cocaine abusers who maintain high levels of a certain receptor in their brain during early abstinence relapse sooner than abusers whose levels drop.

Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.

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