Genetics

Reports on a study involving researchers who successfully desensitized mice to cocaine by genetically altering their dopamine transporters.

Presents research findings linking 89 genes to drug abuse and dependence, found using genome-wide association studies, a new technique for identifying genes.

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

Describes research exploring differences and similarities in the genetic profiles of African-Americans and European-Americans who are heavy smokers.

Describes research providing evidence that genes may influence how successful a person is in quitting smoking and which cessation technique may work best for them.

Discusses the work of NIDA’s Division of Epidemiology, Services and Prevention Research, organized to track drug use and provide empirically based information for researchers and service providers.

Commemorates NIDA’s 35th anniversary and highlights some of the major accomplishments since the Institute’s inception in 1974.

Describes a literature analysis reporting on the prevalence of people with bipolar disorder who also have a substance use disorder and discusses the genetic link that may contribute to this comorbidity.

Highlights NIDA’s research portfolio to identify the genes and genetic processes responsible for a person’s vulnerability to drug abuse.

Reports study results suggesting that genes for several acetylcholine receptor proteins influence early smoking responses and the likelihood of nicotine dependence.