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NIDA

Stimulants

Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

Brain Opioid Receptor Levels Predict Time to Cocaine Relapse

Describes study findings revealing that cocaine abusers who maintain high levels of a certain receptor in their brain during early abstinence relapse sooner than abusers whose levels drop.

Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.

New Tools and Strategies to Bolster Behavioral Therapy

NIDA Director Nora Volkow

Reports on research investigating whether certain medications might strengthen patients' understanding and memory retention.

Crack Cocaine Promotes Progression of HIV Infection to AIDS

Reports on two studies showing a high prevalence of HIV infection and more rapid progression to disability and death among drug abusers.

Brain Adaptation May Dampen Effects of Cocaine

Reports evidence that a cocaine-induced change in the structure of brain cells represents an adaptive response that may limit the drug’s impact.

Stroop Test Identifies Patients at Risk for Treatment Dropout

Reports on a study of cocaine abusers revealing that the Stroop test may predict which cocaine abusers are likely to drop out of therapy.

Low-Cost Incentives Improve Outcomes in Stimulant Abuse Treatment

Reports on a study investigating the use of incentives in the form of prizes to motivate outpatients to stay in behavioral therapy and remain drug free.

Modafinil Normalizes Sleep During Early Cocaine Abstinence

Describes a study investigating the effectiveness of modafinil in enhancing sleep among cocaine abusers who are currently abstinent.

Deep Brain Stimulation Reduces Rats' Cocaine Seeking

Describes results from an animal study involving deep brain stimulation that holds promise as a therapy for severe cocaine addiction.

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