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NIDA

Cocaine

Low Dopamine Receptor Availability May Promote Cocaine Addiction

Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.

Cocaine Locks Rats Into Unrewarding Behaviors

Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.

Drug Cues Outside Awareness Rapidly Trigger Brain's Emotion Centers

Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.

Combined Treatments Improve Dual Abstinence

Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.

Manic Mice Show Heightened Sensitivity to Rewards

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

United States Ranks First in Lifetime Use of Three Drugs

Highlights the disproportionately high rate of Americans who have used cocaine at some time during their lives as compared with other nations surveyed.

Methadone Therapy in Prison Benefits Men a Year Out

Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.

Extended Cocaine Exposure Impairs Cognitive Function in Rats

Reports an animal study presenting evidence that cocaine causes cognitive deficits that can persist well into abstinence.

Test Substance Attenuates Signs of Cocaine Withdrawal in Rats

Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.

Recovery May Be Harder for Adolescents, Animal Study Suggests

Reports animal study findings that suggest adolescents' heightened sensitivity to drug reward puts them at enhanced risk of addiction and may also increase their challenges in recovery.

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