Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.
Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.
Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.
Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.
Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.
Highlights the disproportionately high rate of Americans who have used cocaine at some time during their lives as compared with other nations surveyed.
Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.
Reports an animal study presenting evidence that cocaine causes cognitive deficits that can persist well into abstinence.
Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.
Reports animal study findings that suggest adolescents' heightened sensitivity to drug reward puts them at enhanced risk of addiction and may also increase their challenges in recovery.