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NIDA

Cocaine

Methadone Reduces Rats' Cocaine Seeking

Reports on an animal study showing that methadone, normally used as a therapy for opioid abuse, may prove to be an effective treatment for cocaine abuse.

Long-Term Cocaine Self-Administration Depresses Brain Activity

Discusses research exploring how widespread the reduction of neural activity is in the brain with chronic exposure to cocaine.

New Vaccines Are Being Developed Against Addiction and Relapse

NIDA Director Nora Volkow

Highlights NIDA-funded research to develop vaccines against addiction to drugs such as cocaine, nicotine, phencyclidine (PCP), and methamphetamine.

Aripiprazole Prevents Rats From Resuming Cocaine Seeking

Reports on study results indicating a medication prescribed for schizophrenia and manic phases of bipolar disorder shows promise as a cocaine addiction treatment.

Low Dopamine Receptor Availability May Promote Cocaine Addiction

Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.

Cocaine Locks Rats Into Unrewarding Behaviors

Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.

Drug Cues Outside Awareness Rapidly Trigger Brain's Emotion Centers

Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.

Combined Treatments Improve Dual Abstinence

Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.

Manic Mice Show Heightened Sensitivity to Rewards

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

United States Ranks First in Lifetime Use of Three Drugs

Highlights the disproportionately high rate of Americans who have used cocaine at some time during their lives as compared with other nations surveyed.

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