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NIDA

Cocaine

How Drug Abuse Affects the Brain and Alters Behavior Are Key Questions Driving Division's Work

Discusses the work of NIDA’s Division of Basic Neuroscience and Behavioral Research, the Institute’s locus for studies into the fundamental brain mechanisms underlying drug abuse and addiction.

Cocaine Craving Activates Brain Reward Structures; Cocaine "High" Dampens Them

Reports on a study that documenting changing emotional and neurobiological responses to cocaine with successive doses during a single session of drug taking.

Cocaine Abusers' Pretreatment Cue Responses Predict Recovery Success

Reports on the work of researchers who used brain images to correlate cocaine-addicted patients' regional brain responses to drug cues with their outcomes in subsequent treatment.

Behavioral Response to Novelty Foreshadows Neurological Response to Cocaine

Describes evidence supporting the view that developmental differences in brain systems that use the neurotransmitter dopamine underlie age differences in susceptibility to drug abuse.

Serotonin System May Have Potential as a Target for Cocaine Medications

Describes investigations to advance the development of potential drug abuse relapse prevention agents by targeting specific receptors of the neurochemical serotonin.

Abstinent Patients Continue to Show Benefits of Treatment

Reports on data that reviewing the benefits of addiction treatment among abstinent men as compared with those who continued to abuse cocaine.

Neuropeptide Promotes Drug-Seeking and Craving in Rats

Reports on two studies indicating that orexin, a neuropeptide that stimulates eating and regulates wakefulness, also fosters animals' drug seeking and craving responses to drugs.

Impacts of Drugs on Neurotransmission

Discusses the central importance of studying drugs' effects on neurotransmission and describes some of the most common experimental methods used in this research.

Gene Experiment Confirms a Suspected Cocaine Action

Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.

Cocaine Can Mobilize Stored Dopamine

Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.

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