Discusses research exploring how widespread the reduction of neural activity is in the brain with chronic exposure to cocaine.
Highlights NIDA-funded research to develop vaccines against addiction to drugs such as cocaine, nicotine, phencyclidine (PCP), and methamphetamine.
Reports on study results indicating a medication prescribed for schizophrenia and manic phases of bipolar disorder shows promise as a cocaine addiction treatment.
Describes findings from an animal study showing that cocaine lowers availability of dopamine receptors in the basal ganglia, an area of the brain that includes portions of the reward system.
Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.
Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.
Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.
Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.
Highlights the disproportionately high rate of Americans who have used cocaine at some time during their lives as compared with other nations surveyed.
Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.