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Cocaine

Neuropeptide Promotes Drug-Seeking and Craving in Rats

Reports on two studies indicating that orexin, a neuropeptide that stimulates eating and regulates wakefulness, also fosters animals' drug seeking and craving responses to drugs.

Impacts of Drugs on Neurotransmission

Discusses the central importance of studying drugs' effects on neurotransmission and describes some of the most common experimental methods used in this research.

Gene Experiment Confirms a Suspected Cocaine Action

Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.

Cocaine Can Mobilize Stored Dopamine

Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.

Long-Term Cocaine Abuse Linked With Impaired Heart Function

Summarizes research on the effects of long-term regular cocaine abuse on the cardiovascular system in African Americans.

Chronic Cocaine Abusers Have Occult Insomnia in Early Abstinence

Reports on research of chronic cocaine abusers who may feel they are sleeping better during early abstinence revealed that the opposite may be true.

Mice With Genetic Alteration Eschew Cocaine

Reports on a study involving researchers who successfully desensitized mice to cocaine by genetically altering their dopamine transporters.

Fewer Young Adults Abuse Cocaine and Methamphetamine, National Survey Finds

Reports prevalence rates of illicit drug abuse among youths and young adults based on 2007 data from a national survey of drug use and health.

Reducing Postpartum Drug Use

Highlights a computerized intervention that reduced new mothers' drug abuse in the first 4 months postpartum as reported in a clinical trial of 107 women who abused drugs.

Brain Proteins Differ in Cocaine-Overdose Victims

Describes research findings showing differences in protein concentrations in the brain pleasure centers of people who died from cocaine overdose as compared with those who did not abuse the drug.

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