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NIDA

Cocaine

Digital Addiction Therapies Affirm Promise in Replication and Large Trial

Two computerized programs improved outcomes when they were used to supplement or partially replace in-person behavioral therapy for drug addiction in recent NIDA-sponsored trials.

Narrative of Discovery: Can Magnets Treat Cocaine Addiction?

Two researchers share their reasons for researching transcranial magnetic stimulation (TMS) for treating cocaine addiction, and describe challenges to moving forward this potentially promising therapy.

Why Take a Drug That No Longer Gives Pleasure?

In mice, a cocaine-induced imbalance in the activity of two key populations of neurons in the reward system persists for a longer period after repeated exposure to the drug. For long-term users, this change could both weaken the cocaine “high” and strengthen the compulsion to seek the drug.

NIDA redesigns Easy to Read and Learn the Link websites for mobile devices

The National Institute on Drug Abuse (NIDA) has redesigned two of its websites, Easy to Read and Learn the Link, for use on mobile devices.


Brain Imaging Predicts Relapse to Cocaine

A NIDA-supported study has found that a cocaine-addicted person’s chance of managing 1 whole year of abstinence correlates with activity levels in these impaired motivational and decision-making brain areas.

Do rats prefer palatable foods over meth?

Recent research has shown that most rats will choose non-drug rewards (palatable foods) over self-administering cocaine, if given the option.  A new study by researchers at NIDA’s Intramural Research Program examined whether such a preference generalizes to rats with a history of limited or extended access to another stimulant drug, methamphetamine. 

Study Ranks Recovery Assets in Cocaine Addiction

A can-do attitude, ability to cope with potential triggers for drug use, readiness to change, and participation in self-help programs are major assets for people trying to recover from cocaine addiction.

Biomarkers for Heart Disease Risk in Cocaine Users

Cocaine Abstinence and Reduced Use are Associated with Lowered Marker of Endothelial Dysfunction in African Americans: A Preliminary Study

ECG printout and stethoscope - Stock image
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Dr. Thomas Kosten Q & A: Vaccines To Treat Addiction

In this article and accompanying podcast, Dr. Thomas Kosten discusses the idea and current status of antidrug vaccines to treat substance use and addiction.

Stress Hormone Sets the Stage for Relapse to Cocaine Use

A stressed rat will seek a dose of cocaine that is too weak to motivate an unstressed rat. Researchers traced the physiological pathway that links stress and the stress hormone corticosterone to increased dopamine activity and heightened responsiveness to cocaine.

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