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NIDA

Relapse and Recovery

Combined Treatments Improve Dual Abstinence

Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.

Abstinent Smokers' Nicotinic Receptors Take More Than a Month to Normalize

Describes research revealing that for up to 6 weeks after smokers quit, their brain cells have more nicotine-binding receptors than nonsmokers, which may explain the struggle to quit.

Methadone Therapy in Prison Benefits Men a Year Out

Describes clinical trial results providing evidence that methadone maintenance to men in prison can pay off in better retention in community treatment and reduced drug abuse following their release.

Report Discusses Co-Occurrence of Drug Abuse and Other Mental Disorders

Describes an updated report on the co-occurrence, or comorbidity, of substance use disorders and other psychiatric disorders such as ADHD, schizophrenia, and depression.

Test Substance Attenuates Signs of Cocaine Withdrawal in Rats

Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.

Recovery May Be Harder for Adolescents, Animal Study Suggests

Reports animal study findings that suggest adolescents' heightened sensitivity to drug reward puts them at enhanced risk of addiction and may also increase their challenges in recovery.

Recovery Checkup System Helps Substance Abusers Who Have Mental Disorders

Reports on a posttreatment intervention to support recovery that may be especially beneficial for substance abusers with co-occurring mental disorders.

Rare Glutamate Receptor Proliferates After Cocaine Withdrawal

Reports findings that a rare neuroreceptor may be linked to the intensive cravings cocaine abusers experience during their first weeks of abstinence.

Brain Opioid Receptor Levels Predict Time to Cocaine Relapse

Describes study findings revealing that cocaine abusers who maintain high levels of a certain receptor in their brain during early abstinence relapse sooner than abusers whose levels drop.

Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.

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