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NIDA

Medication Development

Basic Science Discoveries Yield Novel Approaches to Analgesia

Describes research to develop new compounds that match or exceed the pain relief provided by opioids while avoiding their shortcomings.

Lofexidine May Enhance Naltrexone Efficacy

Highlights results from a pilot study suggesting that lofexidine, an anti-hypertensive medication, can enhance success rates among patients taking maintenance naltrexone to avoid opioid relapse.

Selenium Shows Promise as an Adjunct Therapy for HIV

Reports on a randomized controlled trial of HIV-infected men and women who, as a result of receiving selenium supplements, experienced lower HIV viral load and greater CD4 cell count.

New Vaccines Are Being Developed Against Addiction and Relapse

NIDA Director Nora Volkow

Highlights NIDA-funded research to develop vaccines against addiction to drugs such as cocaine, nicotine, phencyclidine (PCP), and methamphetamine.

Aripiprazole Prevents Rats From Resuming Cocaine Seeking

Reports on study results indicating a medication prescribed for schizophrenia and manic phases of bipolar disorder shows promise as a cocaine addiction treatment.

Combined Treatments Improve Dual Abstinence

Reports on a study investigating the effectiveness of a combined therapy of disulfiram and naltrexone for people who abuse cocaine and alcohol.

Naltrexone via Skin Patch Proves Effectiveness of New Technology

Reports on a new device that creates tiny painless punctures in the skin to allow medication to flow evenly from a skin patch into dermal capillaries and the bloodstream.

Test Substance Attenuates Signs of Cocaine Withdrawal in Rats

Reports on several drugs that may ward off depression and anxiety, common withdrawal symptoms from cocaine, based on an animal study.

Medications That Normalize Brain Glutamate Reduce Drug-Seeking in Rats

Reports on two studies that demonstrate the promise of treating addiction with medications that alleviate drug-induced alterations in signaling by the neurotransmitter glutamate.

New Tools and Strategies to Bolster Behavioral Therapy

NIDA Director Nora Volkow

Reports on research investigating whether certain medications might strengthen patients' understanding and memory retention.

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