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Addiction Science

Neuropeptide Promotes Drug-Seeking and Craving in Rats

Reports on two studies indicating that orexin, a neuropeptide that stimulates eating and regulates wakefulness, also fosters animals' drug seeking and craving responses to drugs.

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Impacts of Drugs on Neurotransmission

Discusses the central importance of studying drugs' effects on neurotransmission and describes some of the most common experimental methods used in this research.

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Gene Experiment Confirms a Suspected Cocaine Action

Reports on the work of addiction researchers who are learning how acute and chronic cocaine exposure regulates certain genes, based on knowledge from developmental and cancer biology.

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NIDA Will Contribute to Obesity Research

NIDA Director Nora Volkow

Describes an NIH-wide obesity task force and research plan and explores some of the links between addiction and compulsive eating.

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Researchers Develop a New Tracer for Cannabinoid Receptor

Describes a new chemical tracer that binds specifically to cannabinoid receptors making it potentially useful in future research to clarify the relationship between the receptors and drug abuse.

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Cocaine Can Mobilize Stored Dopamine

Describes a study showing that cocaine, which increases dopamine levels, also can tap into an intracellular dopamine reserve pool.

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Long-Term Cocaine Abuse Linked With Impaired Heart Function

Summarizes research on the effects of long-term regular cocaine abuse on the cardiovascular system in African Americans.

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Not All Mesolimbic Dopamine Neurons Are Alike

Reports on research showing that the neurons that deliver dopamine to two regions of the brain's mesolimbic reward system respond differently to opioids, an important finding for drug treatment research.

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Epigenetics: The Promise of a New Science

NIDA Director Nora Volkow

Discusses the role of epigenetics, the study of cellular mechanisms that control gene expression and its impacts on health and behavior, in addiction research.

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Alcohol Abuse Makes Prescription Drug Abuse More Likely

Reports on results from a study showing that men and women with alcohol use disorders are more likely to report nonmedical use of prescription drugs than people who don't drink at all.

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