En español
NIDA

Basic Science

Cocaine Locks Rats Into Unrewarding Behaviors

Describes research with rats to better understand cocaine’s effect on the neural signaling in the learning circuits of the brain.

Methamphetamine Abuse Alters Response to Facial Cues

Highlights research showing methamphetamine abusers may have more difficulty than nonabusers in responding with empathy and self-control to people who are experiencing intense emotions.

Sensory Aspects of Smoking May Counter Bad Mood, Craving

Describes study findings revealing that the act of smoking, apart from actual or expected nicotine delivery, may soothe a smoker's negative mood.

Drug Cues Outside Awareness Rapidly Trigger Brain's Emotion Centers

Describes research showing that cocaine abusers appear to have a rapid neural response to reward cues outside of their awareness, possibly signifying vulnerability to relapse.

Receptor Complexes Link Dopamine to Long-Term Neuronal Effects

Reports on a discovery of previously unrecognized dopamine receptors in the brain that when triggered by drug abuse lead to potentially long-term neuronal effects.

Manic Mice Show Heightened Sensitivity to Rewards

Reports on an animal study suggesting that the manic stage of bipolar disorder promotes signs of drug abuse vulnerability by enhancing sensitivity to rewards, both natural and drug-related.

Ethnic Groups Have Contrasting Genetic Risks for Nicotine Addiction

Describes research exploring differences and similarities in the genetic profiles of African-Americans and European-Americans who are heavy smokers.

Methamphetamine Turns Helper Cells Into Destroyers

Describes research providing evidence that chronic methamphetamine abuse is associated with increased microglial cell activity in the brain leading to neurodegeneration.

Nicotine Boosts Mood, Brain Dopamine Levels

Highlights findings from a study showing that nicotine triggers a surge in levels of the neurotransmitter dopamine in the brain's main reward area for cigarette smokers.

Extended Cocaine Exposure Impairs Cognitive Function in Rats

Reports an animal study presenting evidence that cocaine causes cognitive deficits that can persist well into abstinence.

Pages

Subscribe to Basic Science