2004
- 2005 Publications > Genetics
of Opiate Addiction
Genetics of Opiate Addiction
- Luo et al, have identified Haplotypes at the OPRM1 locus that
are associated with susceptibility to substance dependence is European-Americans. Am
J Med Genet B Neuropsychiatr Genet. 2003 Jul 1 120(1):97-108.
- Miller et al have discovered a mu-opioid receptor single nucleotide
polymorphism (C77G) in rhesus monkey: that is associated with stress
response and aggression. Mol
Psychiatry. 2004 Jan;9(1):99-108.
- Kest et al, have mapped quantitative trait locus for morphine
withdrawal severity to chromosomes 1, 5 and 10. Mamm
Genome. 2004 Aug;15(8):610-7
- Bart et al have also shown that a substantial attributable
risk related to a functional mu-opioid receptor gene polymorphism A118G
is associated with heroin addiction in central Sweden Molecular
Psychiatry (2004) 9, 547-549
- Yuserov et al have shown that human kappa opioid receptor gene
(OPRK1) haplotypes are associated with opiate addiction in different
ethnic groups and suggest the results are not a consequence of ethnic
stratification Pharmacogenetics.
2004 Dec;14(12):793-804
- Proundnikov et al reports that the 1180 G allele of the 5HT1B receptor
gene is protective1180G protects caucasions from heroin dependence. Pharmacogenet
Genomics. 2006 Jan;16(1):25-36
- Using allele specific gene expression Zhang et al suggest that A118G
allele of the mu opioid receptor results in decreased synthesis of
the A118G variant of the protein J
Biol Chem. 2005 Sep 23;280(38):32618-24.
- Mogil et al reports that Melanocortin-1 receptor gene variants affect
pain and mu-opioid analgesia in mice and humans. J
Med Genet. 2005 Jul;42(7):583-7
- Zachariou et al showed that DeltaFosB overexpression in the NAc increased
the sensitivity of the mice to the rewarding effects of morphine and
led to exacerbated physical dependence, but also reduced their sensitivity
to the analgesic effects of morphine and led to faster development
of analgesic tolerance. The opioid peptide dynorphin seemed to be one
target through which DeltaFosB produced this behavioral phenotype. Nat
Neurosci. 2006 Feb;9(2):205-211
- McClung et al used microarrays of tissue from specific brain regions
involved in morphine responses to identify clusters of genes regulated
by chronic morphine and morphine withdrawal. J
Neurosci. 2005 Jun 22;25(25):6005-15
- Chen et al Found that a signaling cascade composed of Trka/PI3
kinase/AKT1/NF kappa beta mediates delta opioid receptor expression. J
Biol Chem. 2005 Nov 29
- Ippolito et al Found that pain and behavioral stress induce
tyrosine phosphorylation of the potassium channel Kir3.1 likely leading
to physiological adaptation J
Biol Chem. 2005 Dec 16;280(50):41683-93
- Fan et al showed that delta and mu opioid receptor heterooligomers
have properties distinct from delta or mu homooligomers. J
Biol Chem. 2005 Nov 18;280(46):38478-88
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