2004
- 2005 Publications > Genetics
of Alcohol Dependence
Genetics of Alcohol Dependence
- Edenberg et al have shown that variations in GABRA2, encoding
the alpha 2 subunit of the GABA(A) receptor, are associated
with alcohol dependence and with brain oscillations. Am
J Hum Genet. 2004 Apr;74(4):705-14
- Wang et al have identified two different haplotypes
of the muscarinic acetylcholine receptor M2 (CHRM2) gene are
associated with alcohol dependence and major depressive syndrome. Hum
Mol Genet. 2004 Sep 1;13(17):1903-11
- Shirley et al have shown that the expression of mpdz was significantly
associated with severities of withdrawal from alcohol and pentobarbatol,
such that lower expression of mpdz was genetically correlated
with greater withdrawal seizure susceptibility. Findings
may help to identify new targets for pharmacotherapies for withdrawal. Nat.
Neuroscience, 7:699, 2004.)
- Bart et al reports that the A118G variant of the mu
opioid receptor is associated with alcohol dependence in Swedish
population. Neuropsychopharmacology.
2005 Feb;30(2):417-22.
- Lin et al have shown that haplotypes in the vesicular monoamine
transporter2 are protective against becoming an alcoholic. This
is demonstration that many complex disorders will be defects
in regulation of gene expression instead of being mediated by
an amino acid change in the protein. Hum
Mol Genet. 2005 May 15;14(10):1393-404.
- Hinrichs et al report that a functional variant in the bitter
taste receptor (hTASR15) that decreases the perception
of bitter taste increases the risk of alcohol dependence Am
J Hum Genet. 2006 Jan;78(1):103-11.
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