En español

Suboxone® (Buprenorphine/Naloxone) Taper: A Comparison of Two Schedules

Suboxone Buprenorphine/Naloxone Taper

This study was undertaken to compare, in an outpatient setting, the relative advantage of two Suboxone® (Bup/Nx) tapering schedules (one rapid and one gradual) following four weeks of Suboxone® stabilization, as reflected by the proportion of participants providing opiate free urines at the end of the taper regimen. In total, 516 participants were randomized to one of two taper schedules, either 7 days or 28 days. The reason for conducting this study was not to advocate for short-term treatment, but to determine the relative ease of using a more rapid vs. a gradual taper should someone need to discontinue Bup/Nx.

CTN Protocol ID: 
Enrollment Status: 
ClinicalTrials.gov ID: 
Primary Outcomes Article: 

Ling, W., et al. (2009).  Buprenorphine tapering schedule and illicit opioid use.  Addiction 104: 256-265.

Principal Investigator(s)
Walter Ling, M.D.
Integrated Substance Abuse Programs
University of California, Los Angeles
11075 Santa Monica Boulevard
Suite 200
Los Angeles, CA 90025

Available Brochures

Get this Publication

    SAMHSA Treatment Locator

    Blending Initiative

    blending logo

    Formed with SAMHSA to reduce the gap between research results and treatment.