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NIDA

Prescription Opioid Addiction Treatment Study (POATS)

Bottle knocked over with pills on the table

This was a randomized outpatient study for treatment-seeking participants dependent on prescription opioid analgesics. The primary objective was to determine whether the addition of individual drug counseling to the prescription of buprenorphine/naloxone (Bup/Nx) and Standard Medical Management (SMM) improves outcome. Participants were randomized at the beginning of each of two phases to receive BUP/NX paired with either Standard Medical Management (SMM) or Enhanced Medical Management (EMM; defined as SMM plus individual counseling). Six hundred and fifty three participants were randomized into Phase 1, and 360 participants were randomized into Phase 2.

CTN Protocol ID: 
CTN-0030
DSMB ID: 
DSMB-0030
Enrollment Status: 
Completed
ClinicalTrials.gov ID: 
Primary Outcomes Article: 

Weiss, et al. (2011).  Adjunctive counseling during brief and extended buprenorphine-naloxone treatment for prescription opioid dependence.  Archives of General Psychiatry.  68(12):1238-1246.
http://www.ncbi.nlm.nih.gov/pubmed?term=22065255

Principal Investigator(s)
Roger D. Weiss, M.D.
Division of Alcohol and Drug Abuse
McLean Hospital
115 Mill Street
Belmont, MA 2478
rweiss@mclean.harvard.edu

Walter Ling, M.D.
Director
Integrated Substance Abuse Programs
University of California, Los Angeles
11075 Santa Monica Boulevard
Suite 200
Los Angeles, CA 90025
lwalter@ucla.edu

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