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Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment (X:BOT)

This study will assess the comparative effectiveness of extended release injectable naltrexone (XR-NTX) versus buprenorphine-naloxone (BUP-NX) as pharmacotherapeutic aids to recovery amongst treatment-seeking heroin- and/or prescription opioid-dependent participants.  The primary goal of the study is to estimate the difference, if one exists, between XR-NTX and BUP-NX in the distribution of the time to relapse during the 6-month trial.

CTN Protocol ID: 
Enrollment Status: 
Principal Investigator(s)
John Rotrosen, M.D.
NYU School of Medicine
Department of Psychiatry
423 East 23rd Street, 17W
New York, NY 10010

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