Combination Pharmacotherapy for Methamphetamine Dependence: Extended Release Depot Naltrexone + Bupropion vs. Matched Placebos (ADAPT-MD)

This study will investigate the safety and efficacy of a combination pharmacotherapy – extended-release depot naltrexone plus extended-release bupropion for the treatment of methamphetamine dependence.  The double-blind, placebo-controlled study includes random assignment of methamphetamine-dependent participants to one of two conditions: active medication or placebo for 8 weeks of pharmacotherapy provided with weekly psychosocial treatment.