Dr. Rogers, an epidemiologist at the National Institute of Child Health and Human Development, is a masterful manager and leader of a very large multisite study approaching 20 sites, including the data management center. This natural history study has been going on for several years. The next incarnation of the research that she is working on will be an intervention study. She has had the challenge, the experience, and the success of incorporating several additional research questions along the way, from immunology questions to drug abuse questions, and has dealt with how one incorporates new investigators as well as the new science.